Chemical proteomics and discovery of drug targets / 药学学报

Medical community and pharmaceutical companies are currently facing a dire need for discovery and identification of new druggable targets. However, the discovery of small-molecule target is an important and arduous task for the biological and medical scientists. To overcome the bottlenecks for target validation, many new approaches are being developed, such as chemical proteomics. As a part of proteomics approaches, chemical proteomics employs small-molecule compounds that can specifically interact with the target protein to interfere with and detect proteomics. Therefore, new target identification, drug discovery and research on multi-target-directed drugs will all be benefited from the further advances in chemical proteomics approaches. Chemical proteomics has the potential to greatly enhance the efficiency of the drug discovery process.

Optical transport properties along the pericardium meridian under different pressure

This study seeks to discuss the light wave transport characteristics variation along the pericardium Meridian under different pressures. We selected 36 healthy students at the school for this study, tied up the desktop blood pressure cuff onto subjects'right proximal arms, fixed the detection probe immovably on the Neiguan [PC6] acupoint and the reference point which was 1cm off the PC6, and collected the light signal along the meridian and non-meridian when the laser irradiate Jianshi[PC5], Ximen[PC4] and the corresponding reference points respectively under pressure of 0, 100, 130 and 160. The differences in optical transport properties between meridian and nonmeridian were significant: under the same pressures [0s, 100s,130s, and 160mmHg], the relative attenuation rate of optical signal at the same distance between meridian and non-meridian were significant[p<0.001], the optical signal attenuates slower when it transported along meridians; however, there is no significant difference for the relative attenuation rate of optical signal along meridian or non-meridian under different pressures[p>0.05]. Under four different pressure situations, the optical signal at acupoint[PC5] and non-acupoint[NP] along the meridian were significantly different with the corresponding reference points along the non-meridian[P<0.001]; the optical signal on the meridian is stronger than the non-meridian one; the optical signals are strikingly different at acupoints, non-acupoints, and reference points between and 100, 130, and 160mmHg pressures [P